Table 6.

Global and genome-wide methylation markers in rectal cancer patients receiving neoadjuvant chemoradiation.

First Author and Year	Tumor	Overall Population (Treated Patients)	Treatment	Samples	Markers	Methods	Response to Treatment	Other Findings
Tsang, J.S., 2014 [81]	Rectal cancer	53 (53)	Chemoradiation	Tumor tissues	Global methylation	Immunohistochemical staining and image analysis of staining	A significant reduction of global DNA methylation in the majority of patients. Global methylation of pre-treatment specimens was significantly correlated with tumor stage and regression	NA
Gaedcke, J., 2014 [82]	Rectal cancer	185 (185)	Chemoradiation	Tumor tissues	Whole genome methylation	Whole genome methylation CpG island array	Not examined	In a discovery cohort, 20 highly discriminative DMRs were identified. In two additional validation cohorts, 10 DMRs that allowed the discrimination of patients with different prognosis were confirmed