Table 1.

Response surface optimization experiments using DES extraction of investigated variables.

	Experiment Design						Response
No.	Coded Variables			Variables			Extraction Yield (mg/g)
	A	B	C	A (%)	B (°C)	C (mg/mL)
1	0	−1	−1	30	30	30	8.75
2	0	0	0	30	45	50	9.10
3	−1	−1	0	10	30	50	7.62
4	0	0	0	30	45	50	8.90
5	0	0	0	30	45	50	9.15
6	0	−1	1	30	30	70	7.52
7	1	0	−1	50	45	30	7.42
8	1	−1	0	50	30	50	6.93
9	0	1	1	30	60	70	7.72
10	0	0	0	30	45	50	8.70
11	−1	0	−1	10	45	30	8.65
12	1	0	1	50	45	70	6.74
13	−1	0	1	10	45	70	6.56
14	−1	1	0	10	60	50	8.76
15	1	1	0	50	60	50	7.16
16	0	1	−1	30	60	30	8.72
17	0	0	0	30	45	50	9.20