Figure 1.

Concentration–time profiles of freshly spray-dried APIs (SD T₀) shown as blue circles. The crystallized and/or aged spray-dried APIs (SD T_n) are shown as red empty squares. The time point n depends on (i) the time point at which the spray-dried samples completely crystallized or (ii) the last time point of the stability study (i.e., 168 days) if crystallization was incomplete or did not happen (as indicated in Table 1). The apparent crystalline solubility of each API is shown as a black dashed line. The mean ± standard deviation values of three replicates are shown.