Figure 1.

Rotarod performance, horizontal (ambulation) and vertical (rearing) activities, and resting time measured in a computer-aided actimeter in control and lipopolysaccharide (LPS)-lesioned mice orally treated for 28 days after lesion with vehicle (corn oil) or VCE-003.2 at the doses of 10 (VCE 10) or 20 (VCE 20) mg/kg. Data correspond to only one week after the onset of the treatment (post-lesion), or to only one day before the autopsy and after four weeks of treatment (before autopsy). Values are means ± SEM of more than six subjects per group. Data were assessed using the one-way analysis of variance followed by the Bonferroni test.