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. 2019 Jul 25;24(15):2702. doi: 10.3390/molecules24152702

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Intensity of the immunostaining for CD68 measured in a selected area of the substantia nigra pars compacta of control and LPS-lesioned mice orally treated for 28 days after lesion with vehicle (corn oil) or VCE-003.2 at the doses of 10 (VCE 10) or 20 (VCE 20) mg/kg. Immunoreactivity values are measured in the lesioned side over the non-lesioned side, and correspond to means ± SEM of more than 6 subjects per group. Data were assessed using the one-way analysis of variance followed by the Bonferroni test (*** p < 0.005 versus vehicle-treated control (sham) mice). Representative immunostaining images for sham and LPS-lesioned mice treated with vehicle or VCE-003.2 at 20 mg/kg are shown at right (scale bar = 200 µm).