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. 2019 Jul 24;24(15):2686. doi: 10.3390/molecules24152686

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 2 — General synthetic procedure of 5-bromoindole-4-butyramide derivative 30. Reagents and conditions: (a) (i) Ethyl 4-bromobutyrate, Cs₂CO₃, DMF, 100 °C, 16 h; (ii) KOH, DMF/water, 80 °C, 2-6 h, 80%; (b) HOBt, EDAC, CH₂Cl₂, Et₃N, rt, amine: R-NH₂ or HNR¹R², 2-8 h.