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. 2019 Jul 24;24(15):2686. doi: 10.3390/molecules24152686

Table 2.

Cell growth inhibition and anti-migration activity of 5-bromoindole derivatives.

Comp. Inline graphic
R =
GI50 (µM)a Migration (%)b,c
MCF-7 MDA-MB-231
31 graphic file with name molecules-24-02686-i027.jpg >50 >50 99 ± 0.05
32 graphic file with name molecules-24-02686-i028.jpg >50 >50 99 ± 7.78
33 graphic file with name molecules-24-02686-i029.jpg >50 >50 99 ± 0.02
34 graphic file with name molecules-24-02686-i030.jpg 18.4 >50 99 ± 6.60

a GI50 = compound concentration required to inhibit MDA-MB-231 proliferation by 50% after 48 h treatment. Values are expressed as the mean of triplicate experiments, and standard deviation (SD) is <10%. b After 24 h, MDA-MB-231 cellular migration was determined by measuring the distance traveled from the edge of the scratch toward the center of the scratch, relative to control. c Percent relative migration values at 10 µM. Results are presented as means ± SD of three independent experiments.