Table 2.
Comp. |
R = |
GI50 (µM)a | Migration (%)b,c | |
---|---|---|---|---|
MCF-7 | MDA-MB-231 | |||
31 | >50 | >50 | 99 ± 0.05 | |
32 | >50 | >50 | 99 ± 7.78 | |
33 | >50 | >50 | 99 ± 0.02 | |
34 | 18.4 | >50 | 99 ± 6.60 |
a GI50 = compound concentration required to inhibit MDA-MB-231 proliferation by 50% after 48 h treatment. Values are expressed as the mean of triplicate experiments, and standard deviation (SD) is <10%. b After 24 h, MDA-MB-231 cellular migration was determined by measuring the distance traveled from the edge of the scratch toward the center of the scratch, relative to control. c Percent relative migration values at 10 µM. Results are presented as means ± SD of three independent experiments.