Table 1.
Involvement of lysosomal dysfunction in metabolic tissues.
| Metabolic Organ | Characteristics | Results | Reference |
|---|---|---|---|
| Adipose tissue (WAT) | Upregulation of CTSB | Increased lysosomal permeablization in adipocytes and contribution to cell death | Gornicka et al., 2012 [75] |
| Upregulation of CTSB | Involvement in mediating the inflammatory response in cholesterol trafficking | Hannaford et al., 2013 [76] | |
| Downregulation of DAPK2 | Modulation of Lysosome-Mediated Remodeling | Soussi et al., 2015 [77] | |
| Downregulation of CTSL | Autophagosome accumulation | Mizunoe et al., 2017 [78] | |
| Complementary upregulation of CTSB | Inflammasome activation in obese WAT | ||
| Upregulation of CTSB | Contribution to the pathogenesis of obesity-related inflammation | Ju et al., 2019 [79] | |
| Liver | Downregulation of CTSB | Autophagosome accumulation in liver from ob/ob mice | Inami et al., 2011 [80] |
| Downregulation of CTSL | |||
| Downregulation of CTSL, CTSB | patients with NAFLD | Fukuo et al., 2014 [81] | |
| Reduced lysosomal acidity Dysfunction of CTSD maturation |
Defective lysosomal clearance of autophagosomes | Wang et al., 2018 [82] |