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. 2019 Aug 1;24(15):2814. doi: 10.3390/molecules24152814

Scheme 1.

Scheme 1

Synthetic route to thiols 1 and 2. a: 2-Br-methylacetate, Cs2CO3 in ACN(dry), N2, overnight, room temperature (rt); b: 1 M NaOH in MeOH, 2 h, rt; c: pentafluorophenol, EDC.HCl in DCM(dry), N2, overnight, rt; d: hept-6-en-1-ammonium chloride, DIPEA in DCM (dry), N2, overnight, rt; e: 2,2-dimethoxy-1,2-diphenylethan-1-one, thioacetic acid in MeOH, light irradiation (hv) = 254 nm, 1 h, rt; f: 6 M HCl in EtOH, 2 h, reflux; g: 10-Bromothioacetate, K2CO3, NaHCO3 in ACN, 4 h, 40 °C; h: 1 M HCl in EtOH, 2 h, reflux.