Table 2.
Effects of ASC-conditioned medium/secretome on wound healing: In vivo studies.
| ASC Source | Model | Effect | Reference |
|---|---|---|---|
| Human sub-cutaneous adipose tissue. | Rat skin excisional wound model | Stimulation of wound closure, angiogenesis, proliferation, and macrophage infiltration. | [65] |
| Commercial rat ASC. | Rat skin excisional wound model | Accelerated wound closure, increased macrophage recruitment and M2 phenotype polarization. | [67] |
| Adipose tissue of breast cancer patients. | Nude mice full-thickness excisional skin wound model | Stimulation of wound closure, dermal thickening, angiogenesis, and immune cell recruitment. | [46] |
| Commercial human ASCs of normal donors (25–45 years old) undergoing elective surgery. | Rat ischemic skin wound model | Acceleration of wound closure. | [61] |
| Gluteal region of Yorkshire pigs. | Yorkshire pig diabetic skin wound model | Acceleration of wound closure, increased angiogenesis, reduced inflammatory profile. | [68] |
ASCs: adipose tissue-derived stem cells.