Table 5.

Recommendations for further testing of pharmacological agents for chemotherapy-induced peripheral neuropathy prevention or treatment: Comparison to American Society of Clinical Oncology clinical guidelines

ASCO recommendations	Alternative recommendations
CIPN prevention: No further testing due to lack of efficacy or harmful side effects
Acetyl-L-carnitine	Acetyl-L-carnitine
Amifostine	Amifostine
Calcium/magnesium	Calcium/magnesium
Glutathione
Vitamin E
CIPN prevention: Agents recommended for further testing
Goshajinkigan	Alpha-lipoic acid
Venlafaxine	Glutathione
	Goshajinkigan
	Venlafaxine
	Vitamin E
CIPN treatment: No further testing due to lack of efficacy or harmful side effects
Lamotrigine	Topical AK for acute CIPN
CIPN treatment: Agents recommended for further testing
Amitriptyline	Amitriptyline
Gabapentin	Duloxetine
Nortriptyline	Gabapentin
Topical BAK	Nortriptyline
	Lamotrigine
	Topical BAK
	Venlafaxine

CIPN: Chemotherapy-induced peripheral neuropathy, BAK: Baclofen amitriptyline ketamine, AK: Amitriptyline ketamine, ASCO: American Society of Clinical Oncology