Table 4.
Geometric mean daily micronutrient intake during 12 months of follow‐up and difference in intake in children assigned to LNS or control (intent‐to‐treat)
| Micronutrient | Baseline | 3 months | 6 months | 9 months | 12 months | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Control (n = 138) | LNS (n = 160) | Control (n = 128) | LNS (n = 149) | Control (n = 127) | LNS (n = 150) | Control (n = 122) | LNS (n = 128) | Control (n = 111) | LNS (n = 129) | |
| Total vitamin A activity – retinol equivalents (μg) | ||||||||||
| Geometric mean | 214.8 (170.6, 259.0) | 193.8 (159.1, 228.5) | 245.0 (190.0, 300.0) | 457.4 (399.9, 514.9) | 319.8 (238.0, 401.6) | 615.9 (532.4, 699.4) | 313.8 (237.1, 390.4) | 581.0 (510.9, 651.0) | 614.1 (429.3, 798.9) | 670.0 (593.2, 746.8) |
| Difference in mean log vit A † | – | −0.22 | – | 1.02*** | – | 1.02*** | – | 0.84*** | – | 0.63*** |
| Total vitamin B12 (μg) | ||||||||||
| Geometric mean | 0.2 (0.2, 0.3) | 0.1 (0.1, 0.2) | 0.4 (0.3, 0.5) | 0.8 (0.6, 1.0) | 0.8 (0.6, 0.9) | 1.3 (1.1, 1.6) | 0.9 (0.7, 1.1) | 1.3 (1.1, 1.5) | 1.3 (1.1, 1.5) | 1.7 (1.5, 1.9) |
| Difference in mean log vit B12 † | – | −0.30 | – | 1.01*** | – | 0.80*** | – | 0.57** | – | 0.45* |
| Folate (μg) | ||||||||||
| Geometric mean | 63.4 (50.8, 79.1) | 45.9 (37.0, 57.0) | 99.7 (85.6, 116.2) | 159.2 (134.2, 188.9) | 145.2 (130.1, 162.2) | 238.9 (211.2, 270.3) | 151.1 (136.6, 167.1) | 237.1 (213.4, 267.4) | 186.1 (167.9, 206.4) | 283.9 (256.9, 313.7) |
| Difference in mean log folate † | – | −0.30* | – | 0.78*** | – | 0.79*** | – | 0.69*** | – | 0.72*** |
| Iron (mg) | ||||||||||
| Geometric mean | 2.0 (1.6, 2.6) | 1.5 (1.2, 1.9) | 3.3 (2.8, 4.0) | 7.0 (5.7, 8.6) | 5.0 (4.4, 5.7) | 10.6 (9.2, 12.2) | 5.2 (4.5, 5.9) | 10.0 (8.7, 11.4) | 6.3 (5.6, 7.2) | 11.3 (10.0, 12.8) |
| Difference in mean log iron † | – | −0.27 | – | 1.02*** | – | 1.00*** | – | 0.86*** | – | 0.83*** |
| Zinc (mg) | ||||||||||
| Geometric mean | 1.2 (1.0, 1.5) | 0.9 (0.8, 1.1) | 1.9 (1.6, 2.2) | 5.2 (4.3, 6.3) | 3.0 (2.7, 3.4) | 8.1 (6.9, 9.5) | 3.2 (2.8, 3.6) | 7.8 (6.7, 9.1) | 4.0 (3.6, 4.5) | 8.6 (7.4, 9.9) |
| Difference in mean log zinc † | – | −0.24 | – | 1.23*** | – | 1.20*** | – | 1.05*** | – | 0.96*** |
LNS, lipid‐based nutrient supplements. Values are geometric means (95% confidence intervals). *P < 0.05; **P < 0.01; ***P < 0.001. †Differences in mean values and P‐values for the differences were obtained from longitudinal mixed models accounting for clustering at the village and individual levels and controlling for age, breastfeeding status and season. P‐values at baseline indicate the difference between study arms at that time point. P‐values for later visits compare the difference between study arms in change from baseline to that time point.