Table 2.
Single nucleotide polymorphisms (SNPs) that were assayed in the current study: associated chromosomes, nearby genes, and links to hippocampal sclerosis of aging and/or gene expression
| SNPs tested in current study |
Proxy for other SNP |
Chr. | Nearest gene | Linked to HS- Aging risk |
Ref. | Variants | HS-Aging risk allele(s) |
Linked to FTLD- TDP risk |
eQTL for ABCC9 and/or SLCO1C1 |
|---|---|---|---|---|---|---|---|---|---|
| rs5848 | n/a | 17q | GRN | Yes | (Dickson et al., 2010) | C/T | CT/TT | Yes | No |
| rs1990622 | n/a | 7p | TMEM106B | Yes | (Rutherford et al., 2012) | G/A | GA/AA | Yes | No |
| rs704180 | n/a | 12p | ABCC9 | Yes | (Nelson et al., 2014) | G/A | AA | No | Yes |
| rs12301085 | rs73069071 | 12p | SLCO1A2/IAPP | Yes* | (Roostaei et al., 2016) | G/A | GA/AA | No | Yes |
| rs12496790 | rs9637454 | 3q | KCNMB2 | Yes | (Beecham et al., 2014) | G/A | AA | No | No |
*
-Only in persons with rs704180 risk alleles, see Ref. (Nelson et al., 2016a)