Table 3.

Clinical, genetic, pathologic, and biochemical features of the present cohort (n=136), stratified by autopsy-confirmed hippocampal sclerosis of aging (HS-Aging) and advanced Alzheimer’s disease (Braak NFT stages V or VI) pathologies

HS-Aging pathology ? →	HS-Aging no		HS-Aging yes		p-value for Braak V/VI status	p-value for HS- Aging status
Advanced AD (Braak NFT Stages V or VI) pathology ? →	Braak V/VI no	Braak V/VI yes	Braak V/VI no	Braak V/VI yes
n	55	44	13	24	N/A	N/A
Age at death, Avg	85.3	79.5	89.4	86.2	0.032	0.006
% Female	56.4	52.3	69.2	62.5	0.729	0.279
% Normal cognition/clinical state	61.8	7.1	15.4	0.0	<0.001	<0.001
% Demented cognition/clinical state	14.5	81.0	84.6	95.8	<0.001	<0.001
Final MMSE Score, Avg*	27.5	16.0	18.8	11.9	<0.001	<0.001
% SLCO1A2/IAPP risk allele(s)	29.1	18.2	16.7	7.2	0.072	0.992
% GRN risk allele(s)	36.4	43.2	50.0	29.6	0.296	0.490
% TMEM106B risk allele(s)	83.6	79.5	79.2	25.3	0.253	0.518
% ABCC9 risk allele(s)	25.5	15.9	30.8	25.0	0.307	0.472
% APOE ε4 allele [+]*	21.6	37.1	25.0	45.5	0.032	0.270
DG: % [+] TDP-43 inclusions	11	18	77	67	0.321	<0.001
DG: median # inclusions in [+] cases	1.5	1	14	6
CA1: % [+] TDP-43 inclusions	24	18	85	75	0.956	<0.001
CA1: median # inclusions in [+] cases	1	1	13	15.5
CA1 TDP-43 neurites, median	1.05E-03	1.06E-03	3.17E-02	1.05E-02	0.859	<0.001
Sub: % [+] TDP-43 inclusions	11	18	77	67	0.526	<0.001
Sub: median # inclusions in [+] cases	2	3	15	16.5
Sub TDP-43 neurites, median	1.04E-03	1.79E-03	1.41E-02	5.96E-03	0.807	<0.001
% with Frontal Cx TDP-43	1.8	0	8.3	4.1	0.441	0.002
T4 fg/mg brain tissue, Avg	195.8	183.44	182.7	211.89	0.984	0.265
T3 fg/mg brain tissue, Avg	7.58	7.59	7.83	7.91	0.885	0.654
Average of T3/T4 ratio, Avg	0.039	0.041	0.043	0.037	0.861	0.721
PMI (hrs), Avg	4.5	5.0	4.3	5.8	0.051	0.633

^*-APOE genotype was available on 120/136 (88.2%) of the included subjects, and final MMSE scores were available for 126/136 (92.6%) of subjects.

N/A: Not applicable.