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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Pediatr Obes. 2018 Dec 4;14(3):e12479. doi: 10.1111/ijpo.12479

Table 1.

Summary of association results for our Santiago Longitudinal Cohort Study (SLS) compared to previously identified effects in European descent children as reported in Felix et al (2016). SNP – single nucleotide polymorphism; CHR – chromosome; BP – base pair position; EA – effect allele; OA – other allele; EAF - effect allele frequency; β – beta coefficient; SE – standard error, P – P-value

SLS Felix et al.
β (+/− based on EA)
Nearest Gene SNP CHR BP EA/OA EAF Age β SE P
Significant Loci
SEC16B rs543874 1 177889480 G/A 0.27 5 0.126 0.065 0.055 +
10 0.185 0.052 4.3E-04
16 0.164 0.067 0.015
Change 0.0014 0.0019 0.467
ADCY3 rs11676272 2 25141538 G/A 0.34 5 0.064 0.061 0.297 +
10 0.099 0.049 0.043
16 0.061 0.063 0.331
Change −0.0005 0.0018 0.795
FAIM2 rs7132908 12 50263148 A/G 0.22 5 0.033 0.070 0.639 +
10 0.116 0.058 0.046
16 0.059 0.072 0.410
Change 0.0002 0.0012 0.936
OLFM4 rs12429545 13 54102206 A/G 0.32 5 0.090 0.059 0.133 +
10 0.100 0.048 0.037
16 0.042 0.062 0.496
Change −0.0017 0.0017 0.324
FTO rs1421085 16 53800954 C/T 0.22 5 0.060 0.070 0.391 +
10 0.119 0.055 0.032
16 0.177 0.071 0.014
Change 0.0036 0.0020 0.075
Non-Significant Loci
TNNI3K rs12041852 1 75003500 A/G 0.35 10 0.024 0.049 0.628
GPR61 rs7550711 1 110082886 C/T 0.98 10 0.079 0.219 0.715
TMEM18 rs4854349/ 2 647760 G/A 0.87 10 0.102 0.072 0.159 +
rs4854348*
GNPDA2 rs13130484 4 45175691 C/T 0.61 10 0.077 0.048 0.112
TFAP2B rs987237 6 50803050 G/A 0.37 10 0.088 0.051 0.087 +
ELP3 rs13253111/ 8 28060690 A/G 0.59 10 0.043 0.048 0.374 +
rs7821358*
LMX1B rs3829849/ 9 129375338 T/C 0.23 10 0.063 0.058 0.272 +
rs62578126*
RAB27B rs8092503/ 18 52481583 A/G 0.29 10 −0.001 0.052 0.985
rs8085272*
MC4R rs6567160 18 57829135 C/T 0.12 10 0.005 0.071 0.943 +
*

- LD (R2) between Tag and Proxy SNPs ranged from 0.94 to 1.0.