Table 1.
SLS | Felix et al. β (+/− based on EA) |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Nearest Gene | SNP | CHR | BP | EA/OA | EAF | Age | β | SE | P | |
Significant Loci | ||||||||||
SEC16B | rs543874 | 1 | 177889480 | G/A | 0.27 | 5 | 0.126 | 0.065 | 0.055 | + |
10 | 0.185 | 0.052 | 4.3E-04 | |||||||
16 | 0.164 | 0.067 | 0.015 | |||||||
Change | 0.0014 | 0.0019 | 0.467 | |||||||
ADCY3 | rs11676272 | 2 | 25141538 | G/A | 0.34 | 5 | 0.064 | 0.061 | 0.297 | + |
10 | 0.099 | 0.049 | 0.043 | |||||||
16 | 0.061 | 0.063 | 0.331 | |||||||
Change | −0.0005 | 0.0018 | 0.795 | |||||||
FAIM2 | rs7132908 | 12 | 50263148 | A/G | 0.22 | 5 | 0.033 | 0.070 | 0.639 | + |
10 | 0.116 | 0.058 | 0.046 | |||||||
16 | 0.059 | 0.072 | 0.410 | |||||||
Change | 0.0002 | 0.0012 | 0.936 | |||||||
OLFM4 | rs12429545 | 13 | 54102206 | A/G | 0.32 | 5 | 0.090 | 0.059 | 0.133 | + |
10 | 0.100 | 0.048 | 0.037 | |||||||
16 | 0.042 | 0.062 | 0.496 | |||||||
Change | −0.0017 | 0.0017 | 0.324 | |||||||
FTO | rs1421085 | 16 | 53800954 | C/T | 0.22 | 5 | 0.060 | 0.070 | 0.391 | + |
10 | 0.119 | 0.055 | 0.032 | |||||||
16 | 0.177 | 0.071 | 0.014 | |||||||
Change | 0.0036 | 0.0020 | 0.075 | |||||||
Non-Significant Loci | ||||||||||
TNNI3K | rs12041852 | 1 | 75003500 | A/G | 0.35 | 10 | 0.024 | 0.049 | 0.628 | − |
GPR61 | rs7550711 | 1 | 110082886 | C/T | 0.98 | 10 | 0.079 | 0.219 | 0.715 | − |
TMEM18 | rs4854349/ | 2 | 647760 | G/A | 0.87 | 10 | 0.102 | 0.072 | 0.159 | + |
rs4854348* | ||||||||||
GNPDA2 | rs13130484 | 4 | 45175691 | C/T | 0.61 | 10 | 0.077 | 0.048 | 0.112 | − |
TFAP2B | rs987237 | 6 | 50803050 | G/A | 0.37 | 10 | 0.088 | 0.051 | 0.087 | + |
ELP3 | rs13253111/ | 8 | 28060690 | A/G | 0.59 | 10 | 0.043 | 0.048 | 0.374 | + |
rs7821358* | ||||||||||
LMX1B | rs3829849/ | 9 | 129375338 | T/C | 0.23 | 10 | 0.063 | 0.058 | 0.272 | + |
rs62578126* | ||||||||||
RAB27B | rs8092503/ | 18 | 52481583 | A/G | 0.29 | 10 | −0.001 | 0.052 | 0.985 | − |
rs8085272* | ||||||||||
MC4R | rs6567160 | 18 | 57829135 | C/T | 0.12 | 10 | 0.005 | 0.071 | 0.943 | + |
- LD (R2) between Tag and Proxy SNPs ranged from 0.94 to 1.0.