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. Author manuscript; available in PMC: 2020 Jul 15.
Published in final edited form as: Chem Soc Rev. 2019 Jul 15;48(14):3683–3704. doi: 10.1039/c8cs00718g

Fig. 1.

Fig. 1

(A) AuNPs modified with triazacyclononane units can home Zn ions as metal ion centers to mimic phosphodiesterase (PDE). (B) Kinetic profiles of AuNP nanozymes with different side chain modifications in comparison with benchmark HPNPP cleaving bimetallic molecules. Reproduced from ref. 8 with permission from American Chemical Society, copyright 2014. (C) Phosphotriesterase (PTE) like MOF nanozymes hydrolyze a nerve agent simulant dimethyl 4-nitrophenyl phosphate (DMNP). The Zr–OH–Zr moieties established in MOFs mimic the active sites of PTE. Reprinted from ref. 5 with permission from the Royal Society of Chemistry, copyright 2016. (D) Reaction conditions for the hydrolysis of DMNP (upper row) and GD (lower row) in the presence of NU-1000 MOF nanozyme. Time-dependent conversion of DMNP using hydrated (red line) and dehydrated (blue line) NU-1000 were shown in comparison with the background hydrolysis rate (black line). Hydrolysis of GD as a function of time is shown at the lower right panel. Reprinted from ref. 9 with permission from American Chemical Society, copyright 2015.