Table 6.

PASCAL associated genes and interactors. p-values from PASCAL and dbMDEGA meta-analysis are shown for each gene. p-values from dbMDEGA were computed using the p-value method. Heterogeneity values (I²) are also shown. (NA = the gene is not in dbMDEGA).

Gene	p-val PASCAL	p-val dbMDEGA	FDR dbMDEGA	Heterogeneity
XRN2	3.52863316 × 10−9	0.02	0.12	0%
NKX2-4	9.5086814 × 10−9	NA	NA	NA
PLK1S1	4.68346333 × 10−8	NA	NA	NA
KCNN2	3.88782618 × 10−7	0.01	0.11	0%
NKX2-2	7.7773789 × 10−7	0.23	0.37	0%
CRHR1-IT1	1.6858736 × 10−6	NA	NA	NA
C8orf74	1.77348539 × 10−6	0.03	0.16	43%
LOC644172	2.15004243 × 10−6	NA	NA	NA
DDX21	8.86663103 × 10−1	0.3	0.41	69%
ILF2	5.52756293 × 10−1	0.38	0.45	28%
CDKN2AIP	8.21802658 × 10−1	0.04	0.17	0%
EXOSC8	9.41352461 × 10−2	0.1	0.26	64%
NOC3L	3.66793335 × 10−1	0.35	0.44	0%
ACIN1	9.65129025 × 10−1	0.15	0.3	48%
ILF3	1.0116456 × 10−1	0.01	0.1	66%
GNL3	2.39022069 × 10−3	0.01	0.07	67%
KNRNPF	NA	NA	NA	NA
ADAR	1.70702835 × 10−2	0.01	0.1	72%
LYAR	2.30069599 × 10−1	0.03	0.15	0%
SNW1	1.0892706 × 10−1	0.04	0.18	74%
HNRNPK	3.13685174 × 10−1	NA	NA	NA
HNRNPH1	6.07006486 × 10−1	NA	NA	NA
PARN	9.01671731 × 10−1	0	0.03	79%
SUMO2	8.85347296 × 10−1	0.27	0.39	72%
DHX15	2.93250866 × 10−1	0.12	0.38	0%
NOP2	7.85747107 × 10−1	NA	NA	NA
UPF1	2.08668839 × 10−1	0.12	0.27	14%
ALYREF	2.00036414 × 10−1	NA	NA	NA
RBM39	2.90163509 × 10−1	0.06	0.2	18%
SYNCRIP	2.62087002 × 10−1	0.01	0.08	0%
PTBP1	9.27312631 × 10−2	0.02	0.13	0%
C14orf166	2.91369259 × 10−1	0.36	0.44	58%
NONO	NA	0.18	0.33	32%
HNRNPUL1	4.2805356 × 10−1	NA	NA	NA
CALM1	3.30876236 × 10−1	0.4	0.46	27%
CALM2	9.81305815 × 10−1	0.36	0.44	0%
CALM3	7.91761032 × 10−1	0.5	0.5	0%
OLIG2	4.52957535 × 10−1	0.4	0.46	0%