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In vivo murine model. (A) The survival rates of mice infected with NIPH 2061 (K2 capsule type) cells (107 CFU inoculum) were measured after intraperitoneal injection of PBS or the K2 depolymerase (50 μg/mouse) 1 h after challenge. (B) CFU counts of the spleen and liver of mice 12 h after challenge. Significance was determined by Mantel-Cox test (*, P < 0.05).
