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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Kidney Int. 2019 Feb;95(2):321–332. doi: 10.1016/j.kint.2018.09.026

Figure 4 |. Insulin signaling in transient receptor potential cation channel C6 (TRPC6) knockout (KO) podocytes.

Figure 4 |

(a) TRPC6 protein was not detected in KO podocytes. (b,c) Extracellular signal-regulated kinase (ERK) activation was inhibited by TRPC6 KO (decreased phospho-ERK [P-ERK]) at 1 and 10 nM insulin concentrations. (b,d) Phosphorylation of Akt (P-Akt) on threonine 308 (T308) was inhibited at the 10 nM insulin concentration. (b,e) Phosphorylation of Akt on serine 473 (S473) was not significantly affected by TRPC6 KO. *P < 0.05 versus 10 nM insulin in TRPC6+/+ podocytes, †P < 0.01 versus 1 nM insulin in TRPC6+/+ podocytes. To optimize viewing of this image, please see the online version of this article at www.kidney-international.org.