Table 3 |.

Effect of TRPC6 KO on glomerular volume and podocyte number in Akita mice

Experimental group	Glomerular volume (×105 μm3)	No. of podocytes per glomerular profile	No. of podocytes per glomerulus	NV (P/Glom) (×10−5/μm3)
Nondiabetic WT mice (n = 7)	2.54 ± 0.12	8.57 ± 0.27	51.8 ± 1.7	22.3 ± 0.7
Nondiabetic KO mice (n = 6)	1.92 ± 0.07	8.02 ± 0.29	52.3 ± 1.9	29.5 ± 1.1a
WT Akita mice (n = 8)	3.92 ± 0.31b (153%)c	6.88 ± 0.16a (80%)c	50.7± 0.9 (97%)c	14.2 ± 0.3b (63%)c
KO Akita mice (n = 12)	2.92 ± 0.18d,e (153%)f	7.55 ± 0.18 (94%)f	48.6 ± 1.2 (93%)f	17.9 ± 0.4f,g (60%)f

KO, knockout; n, number of mice in each group; NV (P/Glom), numerical density of podocytes in glomeruli; WT, wild type.

^aP < 0.05 versus nondiabetic WT mice.

^bP < 0.001 versus nondiabetic WT mice.

^cPercentage of nondiabetic WT mice.

^dP < 0.05 versus nondiabetic KO mice.

^eP < 0.01 versus WT Akita mice.

^fPercentage of nondiabetic KO mice.

^gP < 0.001 versus nondiabetic KO mice.