Table 3.

Difference in mean log telomere length per 1 or 10 unit increase in allostatic load biomarker

Allostatic load biomarker	Unadjusted $\widehat{\beta }$ (95% CI)	Adjusted for age $\widehat{\beta }$ (95% CI)
Inflammatory markers
C-reactive protein (mg/dL)	−0.012 (−0.040, 0.015)	−0.009 (−0.037, 0.019)
Serum albumin (g/dL)	−0.003 (−0.072, 0.065)	−0.012 (−0.082, 0.057)
Metabolic factors
Body mass index (kg/m2)	−0.003 (−0.005, 0.000)	−0.002 (−0.005, 0.000)
Glycohaemoglobin (%)	−0.021 (−0.037, −0.005)	−0.014 (−0.031, 0.002)
Cardiovascular markers
Systolic blood pressure (mmHg)a	−0.011 (−0.020, −0.002)	−0.005 (−0.014, 0.004)
Diastolic blood pressure (mmHg)a	−0.019 (−0.032, −0.007)	−0.010 (−0.023, 0.003)
High-density lipoprotein (mg/dL)a	0.008 (0.000, 0.016)	0.012 (0.004, 0.020)
Total cholesterol (mg/dL)a	−0.004 (−0.008, −0.001)	−0.002 (−0.005, 0.002)
Triglyceride (mg/dL)ab	−0.001 (−0.003, 0.001)	0.000 (−0.002, 0.002)
Homocysteine (μmol/L)ac	−0.003 (−0.060, 0.054)	0.016 (−0.039, 0.071)
Pulse (beats/min)a	−0.005 (−0.019, 0.010)	−0.008 (−0.022, 0.006)
Other marker
Serum creatinine (mg/dL)	0.014 (−0.027, 0.055)	0.020 (−0.022, 0.062)
Urine creatinine (mg/dL)a	0.000 (−0.003, 0.003)	−0.001 (−0.004, 0.003)
Creatinine clearance (mL/min)a	−0.003 (−0.007, 0.001)	−0.004 (−0.008, 0.000)

Beta coefficients and 95% confidence interval from simple or multiple (included continuous age as covariate) linear regression with log-transformed telomere length as the dependent variable.

CI, confidence interval.

^aPer 10 unit increase in biomarker.

^bTriglycerides were measured in morning fasting subsample. Separate subsample weights were available to reweight this subsample to reflect national data.

^cHomocysteine values from 1999–2000 were converted to 2001–2002 assay values using the following equation: new homocysteine = 10 * (0.983 * log₁₀ (old homocysteine) + 0.0418). Reference: http://wwwn.cdc.gov/nchs/nhanes/2003-2004/L06MH_C.htm.