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. Author manuscript; available in PMC: 2019 Aug 16.
Published in final edited form as: Environ Sci Technol. 2018 Apr 11;52(9):5417–5426. doi: 10.1021/acs.est.7b06145

Table 1.

Results for the top 20 ranked chemical samples that demonstrated significant RAIU inhibition in multi-concentration screening

Chemical CAS NO. Max Conc(M)a AC50 absEC50 Cytotox-pointb Ranking Score Non-cytotoxic RAIU inhibition at 1 or 2 concentrationsc
1 Etoxazole 153233-91-1 1.00E-04 −5.92 −5.88 −4.32 150.41 +
2 Triphenyltin hydroxide 76-87-9 1.00E-04 −5.39 −5.39 −5.17 114.70 −
3 Niclosamide 50-65-7 5.00E-05 −6.95 −6.79 −6.91 109.38 −
4 3-Iodo-2-propynyl-N-butylcarbamate 55406-53-6 1.00E-04 −5.09 −5.30 −4.80 107.61 +
5 PFOS 1763-23-1 8.00E-05 −4.75 −4.78 −4.09 94.75 +
6 PFOS 1763-23-1 8.00E-05 −4.72 −4.74 NA 93.63 +
7 Cyprodinil 121552-61-2 1.00E-04 −4.43 −4.43 NA 89.12 +
8 Rotenone 83-79-4 1.00E-04 −7.15 −6.22 −7.30 86.15 +
9 Pyridaben 96489-71-3 1.00E-04 −8.64 −7.49 −7.60 78.17 −
10 Methoxyfenozide 161050-58-4 1.00E-04 −4.78 −4.72 −4.68 76.97 +
11 2-(Thiocyanomethylthio)benzothiazole 21564-17-0 1.00E-04 −4.33 −4.37 −4.91 71.48 −
12 Oxyfluorfen 42874-03-3 1.00E-04 −4.55 −4.39 NA 68.27 +
13 Captan 133-06-2 9.50E-05 −4.49 −4.50 −4.81 65.79 −
14 Fipronil 120068-37-3 1.00E-04 −4.57 −4.63 −4.92 64.32 +
15 Fluroxypyr-meptyl 81406-37-3 1.00E-04 −4.77 −4.74 −4.74 64.10 +
16 Cyhalofop-butyl 122008-85-9 9.50E-05 −5.47 −4.75 −5.07 58.47 −
17 Fenpyroximate (Z,E) 111812-58-9 1.00E-04 −6.79 −6.07 −7.09 57.34 −
18 Thiobencarb 28249-77-6 1.00E-04 −4.38 −4.34 −4.70 55.20 −
19 Emamectin benzoate 155569-91-8 1.00E-04 −4.88 −4.99 −5.18 54.82 −
20 Diphenylamine 122-39-4 1.00E-04 −4.74 −4.28 −5.59 54.01 −

Results for all test chemicals are in Table S1.

a

Max Conc: the maximum permissible concentration tested in single-concentration screening. The Max Conc was obtained by 200X dilution of the supplied stock chemicals (concentrations ≤ 20mM). Serial dilution of samples for multi-concentration assay started with the Max Conc.

b

Cytotox-point: the log concentration where the chemical started to show significant toxicity (absEC82.3). NA: not available, as no significant cytotoxicity was observed.

c

Non-cytotoxic RAIU inhibition at 1 or 2 concentrations: show chemicals that have significant RAIU inhibition without significant cytotoxicity at one or two concentrations tested in multi-concentration screening. +: yes, -: no.