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. Author manuscript; available in PMC: 2019 Nov 8.
Published in final edited form as: Nature. 2019 May 8;569(7757):503–508. doi: 10.1038/s41586-019-1186-3

Fig. 2. DNA methylation and cancer dependence.

Fig. 2

a, Global correlation between DNA methylation and gene dependency of the same gene or associated genes (StringDB). Top pairs (q < 5 × 10−5) are labelled (n = 45–380; Supplementary Table 8). b, c, Hypomethylation of SOX10 in melanoma cell lines is associated with SOX10 mRNA expression (Pearson’s r = −0.82, n = 824, P < 2.2 × 10−16) (b) and sensitivity to SOX10 knockdown (Pearson’s r = 0.79, n = 376, P < 2.2 × 10−16) (c). RPKM, reads per kilobase of transcript per million mapped reads. d, Promoter hypermethylation of RPP25 is a marker for vulnerability to RPP25L knockout (Pearson’s r = −0.71, n = 369, P < 2.2 × 10−16). e, LDHB methylation confers sensitization to LDHA knockout (Pearson’s r = −0.52, n = 362, P < 2.2 × 10−16).