TABLE 2.
Odds ratios and 95% confidence intervals of colorectal adenomas for 17 candidate single nucleotide polymorphisms in genes related to inflammatory response and obesity among cases and controls in the CLUE II cohort of Washington County, MD 1989
| Genotype | Cases, n | Controls, n | OR (95%CI)a |
|---|---|---|---|
| IL10 | |||
| rs1800896 | |||
| A/A | 39 | 75 | 1.00 (Ref) |
| A/G | 63 | 127 | 0.94 (0.59–1.52) |
| G/G | 32 | 61 | 1.01 (0.58–1.77) |
| ptrendb | 0.98 | ||
| G-carrier | 95 | 188 | 0.97 (0.62–1.51) |
| rs1800872 | |||
| C/C | 80 | 147 | 1.00 (Ref) |
| A/C | 46 | 76 | 1.12 (0.71–1.78) |
| A/A | 6 | 23 | 0.42 (0.15–1.16) |
| ptrendb | 0.38 | ||
| A-carrier | 52 | 99 | 0.97 (0.62–1.50) |
| CRP | |||
| rs1800947 | |||
| G/G | 115 | 239 | 1.00 (Ref) |
| C/G | 16 | 22 | 1.57 (0.79–3.13) |
| C/C | 2 | 1 | 4.36 (0.93–48.45) |
| ptrendb | 0.09 | ||
| C-carrier | 18 | 23 | 1.68 (0.86–3.28) |
| rs1205 | |||
| C/C | 52 | 131 | 1.00 (Ref) |
| C/T | 60 | 95 | 1.65 (1.03–2.65) |
| T/T | 19 | 30 | 1.72 (0.87–3.38) |
| ptrendb | 0.04 | ||
| T-carrier | 79 | 125 | 1.67 (1.07–2.60) |
| TLR4 | |||
| rs4986790 | |||
| A/A | 119 | 228 | 1.00 (Ref) |
| G-carrierc | 14 | 32 | 0.83 (0.43–1.57) |
| rs11536889 | |||
| G/G | 94 | 191 | 1.00 (Ref) |
| C/G | 36 | 66 | 1.11 (0.70–1.78) |
| C/C | 4 | 4 | 2.06 (0.51–8.26) |
| ptrendb | 0.38 | ||
| C-carrier | 40 | 70 | 1.17 (0.74–1.84) |
| IL6 | |||
| rs1800797 | |||
| G/G | 46 | 79 | 1.00 (Ref) |
| A/G | 71 | 123 | 0.96 (0.61–1.51) |
| A/A | 17 | 52 | 0.53 (0.27–1.05) |
| ptrendb | 0.12 | ||
| A-carrier | 88 | 175 | 0.85 (0.55–1.31) |
| rs1800796 | |||
| G/G | 118 | 229 | 1.00 (Ref) |
| C-carrierc | 13 | 15 | 1.63 (0.75–3.58) |
| rs1800795 | |||
| G/G | 43 | 68 | 1.00 (Ref) |
| C/G | 68 | 126 | 0.86 (0.54–1.38) |
| C/C | 21 | 47 | 0.74 (0.38–1.44) |
| ptrendb | 0.36 | ||
| C-carrier | 89 | 173 | 0.84 (0.53–1.32) |
| IL1B | |||
| rs1143627 | |||
| T/T | 57 | 119 | 1.00 (Ref) |
| C/T | 59 | 102 | 1.26 (0.80–1.97) |
| C/C | 17 | 35 | 1.02 (0.54–1.94) |
| ptrendb | 0.65 | ||
| C-carrier | 76 | 137 | 1.19 (0.78–1.81) |
| IL8 | |||
| rs4073 | |||
| T/T | 47 | 88 | 1.00 (Ref) |
| A/T | 62 | 109 | 1.04 (0.64–1.69) |
| A/A | 24 | 52 | 0.84 (0.46–1.54) |
| ptrendb | 0.61 | ||
| A-carrier | 86 | 161 | 0.97 (0.61–1.54) |
| TNF | |||
| rs1800629 | |||
| G/G | 94 | 181 | 1.00 (Ref) |
| A/G | 35 | 68 | 1.00 (0.63–1.58) |
| A/A | 3 | 10 | 0.60 (0.16–2.20) |
| ptrendb | 0.65 | ||
| A-carrier | 38 | 78 | 0.95 (0.61–1.49) |
| RNASEL | |||
| rs486907 | |||
| G/G | 62 | 102 | 1.00 (Ref) |
| A/G | 54 | 108 | 0.80 (0.51–1.26) |
| A/A | 15 | 35 | 0.71 (0.36–1.39) |
| ptrendb | 0.23 | ||
| A-carrier | 69 | 143 | 0.78 (0.51–1.18) |
| PPARG | |||
| rs1801282 | |||
| C/C | 100 | 180 | 1.00 (Ref) |
| C/G | 28 | 63 | 0.82 (0.50–1.35) |
| G/G | 4 | 7 | 1.08 (0.89–3.94) |
| ptrendb | 0.57 | ||
| G-carrier | 32 | 70 | 0.85 (0.54–1.35) |
| TCF7L2 | |||
| rs7903146 | |||
| C/C | 63 | 115 | 1.00 (Ref) |
| C/T | 51 | 108 | 0.86 (0.54–1.36) |
| T/T | 15 | 23 | 1.16 (0.56–2.39) |
| ptrendb | 0.98 | ||
| T-carrier | 66 | 131 | 0.92 (0.59–1.41) |
| ADIPOQ | |||
| rs1501299 | |||
| C/C | 60 | 131 | 1.00 (Ref) |
| A/C | 66 | 95 | 1.58 (1.00–2.49) |
| A/A | 7 | 32 | 0.44 (0.18–1.08) |
| ptrendb | 0.87 | ||
| A-carrier | 73 | 127 | 1.28 (0.83–1.96) |
| LEP | |||
| rs2167270 | |||
| G/G | 50 | 111 | 1.00 (Ref) |
| A/G | 71 | 119 | 1.39 (0.88–2.20) |
| A/A | 13 | 29 | 1.04 (0.48–2.24) |
| ptrendb | 0.44 | ||
| A-carrier | 84 | 148 | 1.33 (0.85–2.06) |
a
From a conditional logistic regression model where cases and controls were matched on age, sex, race, and date of blood draw.
b
Tests for trend evaluated by entering into the model an ordinal variable representing the number of minor alleles.
c
ORs for minor homozygotes not estimable because of zero counts in cases or controls.