Table 2.

The relationship of BPE to microvessel density, CD34, glandular concentration and VEGF in pre-menopausal patients

Variable	Category	BPE				ra	pa
		Min (n = 12)	Mild (n = 14)	Mod (n = 13)	Marked (n = 9)
Microvessel densityb	< 3	8 (67%)	4 (29%)	0 (0%)	0 (0%)	0.71	< 0.001
	3−	4 (33%)	6 (43%)	6 (38%)	1 (11%)
	5+	0 (0%)	4 (29%)	7 (15%)	8 (89%)
	Averagec	1.33	2.00	2.54	2.89
CD34d	+	11 (92%)	7 (50%)	2 (69%)	1 (11%)	0.71	< 0.001
	++	1 (8%)	6 (43%)	8 (26%)	0 (0%)
	+++	0 (0%)	1 (7%)	3 (3%)	8 (89%)
	Averagec	1.08	1.57	2.08	2.78
Glandular concentratione	Low	11 (92%)	7 (50%)	2 (15%)	1 (11%)	0.70	< 0.001
	Medium	1 (8%)	6 (43%)	4 (31%)	1 (11%)
	High	0 (0%)	1 (7%)	7 (54%)	7 (78%)
	Averagec	1.08	1.57	2.38	2.67
VEGFf	+	11 (92%)	9 (64%)	2 (15%)	1 (11%)	0.67	< 0.001
	++	1 (8%)	4 (29%)	8 (62%)	3 (33%)
	+++	0 (0%)	1 (7%)	3 (23%)	5 (56%)
	Averagec	1.08	1.43	2.08	2.44
Spearman correlations between pathological variablesg
Variable	(1)	(2)		(3)		(4)
(1) MVD	1.00	0.78		0.78		0.79
(2) CD34		1.00		0.95		0.89
(3) Glan con				1.00		0.92
(4) VEGF						1.00

BPE measurements made by JSS

^aNon-parametric Spearman correlation (r) with associated 2-sided significance level (p)

^bPer 200 × HPF

^cAverages scoring 3 levels as 1, 2 and 3 respectively

^dMembranous staining of endothelial cells

^eAs a proportion of the FGT

^fMembranous staining of TDLU epithelial cells

^gAll p values < 0.001