TABLE 1.
Neuropsychiatric Toxicity of Adolescent SC Exposures Compared With Cannabis Exposures
| Neuropsychiatric Sign or Symptom | SC Only, N (%) | Cannabis Only, N (%) |
OR (95% CI) | SC-Polydrug Use, N (%) |
Cannabis-Polydrug Use, N (%) |
OR (95% CI) |
|---|---|---|---|---|---|---|
| Agitation | 23 (23.5) | 54 (62.8) | 0.18 (0.10−0.34)*** | 18 (47.4) | 24 (20.9) | 3.11 (1.56−7.44)*** |
| Coma and/or CNS depression | 28 (28.5) | 9 (10.5) | 3.42 (1.51−7.75)*** | 7 (18.4) | 30 (26.1) | 0.64 (0.26−1.61) |
| Delirium and/or toxic psychosis | 17 (17.4) | 10 (11.6) | 1.60 (0.69−3.70) | 14 (36.8) | 28 (24.3) | 1.81 (0.83−3.97) |
| EPS, dystonia, and/or rigidity | 2 (2.0) | 2 (2.3) | 0.88 (0.12−6.35) | 1 (2.63) | 7 (6.1) | 0.42 (0.05−3.50) |
| Hallucinations | 7 (7.1) | 13 (15.1) | 0.43 (0.16−1.14) | 6 (15.8) | 13 (11.3) | 1.47 (0.51−4.19) |
| Seizures | 19 (19.4) | 5 (5.8) | 3.89 (1.39−10.94)*** | 11 (28.9) | 9 (7.8) | 4.80 (1.80−12.74)*** |
***
P < .01.