Table 10:
Lists of chemicals with overall positive /negative calls in both TGR and comet assays (data curation approach)
| A: Liver | |||
|---|---|---|---|
| TGR +/ comet + (24) | TGR +/comet − (4) | TGR −/ comet + (1) | TGR −/comet − (4) |
| 1-Ethyl-1-nitrosourea | 4-Aminobiphenyl (free base + HCL salt) | Ethyl acrylate | Allura Red AC (Food Red 40) |
| 2-Acetylaminofluorene | Chlorambucil | Chloroform | |
| 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhiP - free base & HCl salt) | Chromium (hexavalent) | Hydroquinone | |
| 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) | Methyleugenol | Methylphenidate HCl | |
| 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) | |||
| 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ - free base & HCL salt) | |||
| 5,9-Dimethyldibenzo[c,g]carbazole | |||
| Acrylamide | |||
| Aflatoxin B1 | |||
| Aristolochic acids I and II (and sodium salt) | |||
| beta-Propiolactone | |||
| Cisplatin | |||
| Cyclophosphamide (free base and monohydrate) | |||
| Cyproterone acetate | |||
| Dichlorvos | |||
| Dicyclanil | |||
| N-Nitrosodiethylamine (diethylnitrosamine) | |||
| N-Nitrosodimethylamine (dimethylnitrosamine) | |||
| N-Nitrosodipropylamine [dipropylnitrosamine] | |||
| N-Nitroso-N-methylurea | |||
| N-Nitrosopyrrolidine | |||
| Procarbazine HCl (natulan)/procarbazine | |||
| Urethane | |||
| Wyeth 14,643 | |||
| B: Stomach and colon | |||
| Stomach | |||
| TGR +/ comet + (4) | TGR +/comet − (0) | TGR −/ comet + (1) | TGR −/comet − (0) |
| 4-Nitroquinoline-N-oxide | Ethyl acrylate | ||
| Benzo[a]pyrene | |||
| beta-Propiolactone | |||
| N-Methyl-N'-nitro-N-nitrosoguanidine | |||
| Colon | |||
| TGR +/ comet + (8) | TGR +/comet − (0) | TGR −/ comet + (0) | TGR −/comet − (0) |
| 1-Ethyl-1-nitrosourea | |||
| 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhiP - free base & HCl salt) | |||
| 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) | |||
| 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) | |||
| 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ - free base & HCL salt) | |||
| 7,12-Dimethylbenz[a]anthracene | |||
| Benzo[a]pyrene | |||
| C.I. Solvent yellow 3 (o-aminoazotoluene) | |||
| C: Bone marrow | |||
| TGR +/ comet + (5) | TGR +/comet − (5) | TGR −/ comet + (0) | TGR −/comet − (0) |
| 4-Nitroquinoline-N-oxide | 1,3-Butadiene | ||
| Aristolochic acids I and II (and sodium salt) | 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) | ||
| Mitomycin C | Benzo[a]pyrene | ||
| N-Nitroso-N-methylurea | Chlorambucil | ||
| Procarbazine HCl (natulan)/procarbazine | Urethane | ||