Table 6:
Lists of chemicals with overall positive/negative results in both TGR and comet assays (WoE approach)
| A: Liver | |||
|---|---|---|---|
| TGR +/ comet + (23) | TGR +/comet− (3) | TGR −/ comet + (4) | TGR −/comet − (5) |
| 1-Ethyl-1-nitrosourea | 4-Aminobiphenyl (free base + HCL salt) | 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (AKA MX) | Allura Red AC (Food Red 40) |
| 2,4-Diaminotoluene (free base and 2HCl salt) | Chlorambucil | Acetaminophen | Chloroform |
| 2-Acetylaminofluorene | Methyleugenol | Benzene | Hydroquinone |
| 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) | Ethyl acrylate | Methylphenidate HCl | |
| 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ - free base & HCL salt) | Nitrite, sodium | ||
| 5,9-Dimethyldibenzo[c,g]carbazole | |||
| Acrylamide | |||
| Aflatoxin B1 | |||
| Aristolochic acids I and II (and sodium salt) | |||
| beta-Propiolactone | |||
| Cyclophosphamide (free base and monohydrate) | |||
| Cyproterone acetate | |||
| Dichlorvos | |||
| Dicyclanil | |||
| Ethyl methanesulphonate | |||
| Methyl methanesulphonate | |||
| N-Nitrosodiethylamine | |||
| N-Nitrosodimethylamine | |||
| N-Nitrosodipropylamine | |||
| N-Nitroso-N-methylurea | |||
| N-Nitrosopyrrolidine | |||
| Urethane | |||
| Wyeth 14,643 | |||
| B: GI tract | |||
| TGR +/ comet + (14) | TGR +/comet − (0) | TGR −/ comet + (3) | TGR −/comet − (2) |
| 1-Ethyl-1-nitrosourea | Chromium (hexavalent) | Hydroquinone | |
| 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhiP - free base & HCl salt) | Ethyl acrylate | Nitrite, sodium | |
| 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) | N-Nitrosodimethylamine | ||
| 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) | |||
| 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ - free base & HCL salt) | |||
| 4-Nitroquinoline-N-oxide | |||
| 7,12-Dimethylbenz[a]anthracene | |||
| Benzo[a]pyrene | |||
| beta-Propiolactone | |||
| C.I. Solvent yellow 3 (o-aminoazotoluene) | |||
| Methyl methanesulphonate | |||
| N-Methyl-N'-nitro-N-nitrosoguanidine | |||
| N-Nitroso-N-methylurea | |||
| Urethane | |||
| C: Bone marrow | |||
| TGR +/ comet + (7) | TGR +/comet − (5) | TGR −/ comet + (1) | TGR −/comet − (2) |
| 4-Nitroquinoline-N-oxide | 1,3-Butadiene | N-Nitrosodipropylamine | 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhiP - free base & HCl salt) |
| 7,12-Dimethylbenz[a]anthracene | 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) | Acrylonitrile | |
| Acrylamide | Benzo[a]pyrene | ||
| Ethyl methanesulphonate | Chlorambucil | ||
| Mitomycin C | Urethane | ||
| N-Nitroso-N-methylurea | |||
| Procarbazine HCl (natulan)/procarbazine | |||