Table 5.
Absolute CD4 Counts and HIV Viral Loads From Collected Samples of Study Patients at Baseline, During VOR Chemotherapy, and After Completion of Treatment
| Patient ID/Laboratory Test | Current ART | VOR Dose Level, mg | Baseline | After Cycle 2 | Posttreatment | ||
|---|---|---|---|---|---|---|---|
| 1 mo | 6 mo | 12 mo | |||||
| 075–061-001 | RTV, DRV, FTC, TDF | 300 | |||||
| Absolute CD4 count, cells/μl | 178 | 321 | 234 | 359 | – | ||
| HIV VL, copies/ml | 282,977 | 92 | 54 | UD (<48) | – | ||
| 075–041-002 | EFV, FTC, TDF | 300 | |||||
| Absolute CD4 count, cells/μl | 426 | 384 | 394 | – | – | ||
| HIV VL, copies/ml | UD (<20) | UD (<20) | UD (<20) | – | – | ||
| 075–061-003 | Started after cycle 1 | 300 | |||||
| Absolute CD4 count, cells/μl | 258 | 458 | 212 | 334 | – | ||
| HIV VL, copies/ml | 55,116 | 764 | UD (<48) | UD (<48) | – | ||
| 075–031-013 | FTC, ETR, TDF | 300 | |||||
| Absolute CD4 count, cells/μl | 91 | 100 | 38 | – | – | ||
| HIV VL, copies/ml | 22,400 | 322 | 235,000 | – | – | ||
| 075–150-014 | FTC, NVP, TDF | 300 | |||||
| Absolute CD4 count, cells/μl | 754 | 810 | 445 | – | – | ||
| HIV VL, copies/ml | 9034 | 2076 | UD (<40) | – | – | ||
| 075–120-016 | 3TC, EFV, FTC, TDF | 300 | |||||
| Absolute CD4 count, cells/μl | 279 | 407 | 338 | 354 | 448 | ||
| HIV VL, copies/ml | UD (<20) | 30 | UD (<20) | UD (<75) | UD (<20) | ||
| 075–041-004 | FTC, ETR, RAL | 400 | |||||
| Absolute CD4 count, cells/μl | 134 | 183 | 227 | 341 | 284 | ||
| HIV VL, copies/ml | UD (<48) | 46 | UD (<20) | UD (<20) | UD (<20) | ||
| 075–080-006 | ABC, 3TC, NVP | 400 | |||||
| Absolute CD4 count, cells/μl | 269 | 282 | 237 | 314 | 373 | ||
| HIV VL, copies/ml | UD (<20) | UD (<20) | 549 | UD (<20) | 548 | ||
| 075–060-007 | Started after cycle 1 | 400 | |||||
| Absolute CD4 count, cells/μl | 186 | 125 | 137 | 157 | 150 | ||
| HIV VL, copies/ml | 482,000 | 1000 | UD (<48) | UD (<48) | UD (<20) | ||
| 075–152-009 | EFV, FTC, TDF | 400 | |||||
| Absolute CD4 count, cells/μl | 485 | 412 | 218 | 357 | 350 | ||
| HIV VL, copies/ml | UD (<40) | UD (<40) | 49 | UD (<40) | UD (<40) | ||
| 075–080-011 | RTV, DRV, RAL | 400 | |||||
| Absolute CD4 count, cells/μl | 96 | 64 | 136 | 126 | 126 | ||
| HIV VL, copies/ml | 88 | 22 | 23 | 2419 | 4377 | ||
| 075–041-012 | RTV, MVC, RAL | 400 | |||||
| Absolute CD4 count, cells/μl | 109 | 221 | – | – | – | ||
| HIV VL, copies/ml | 25 | UD (<20) | – | – | – | ||
Abbreviations: ABC = abacavir; ART = antiretroviral therapy; DRV = darunavir; EFV = efavirenz; ETR = etravirine; FTC = emtricitabine; LPV = lopinavir; MVC = maraviroc; NPV = nevirapine; RAL = raltegravir; RTV = ritonavir; 3TC = lamivudine; TDF = tenofovir; UD = undetectable; VL = viral load; VOR = vorinostat.