REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-human Ki-67 Antibody-605	BioLegend	Cat# 350522
Anti-Fibronectin antibody-647	abcam	Cat# ab198934
Anti-ERK1/2 Phospho (Thr202/Tyr204) Antibody-PE	BioLegend	Cat# 369506
Anti-STAT3 Phospho (Tyr705) Antibody-421	BioLegend	Cat# 651010
Anti-Cytokeratin 7 antibody-488	abcam	Cat# ab185048
Bacterial and Virus Strains
pBABE-hygro-hTERT	addgene	Cat# 1773
Chemicals, Peptides, and Recombinant Proteins
pUltra-hot-mCherry		Cat# 24130
Critical Commercial Assays
Tissue RNA-ISH Staining (2-plex)	ThermoFisher	Cat# QVT0012
Deposited Data
RNA sequencing	This paper	GEO: GSE113616
Proteomic Data	This paper	MassIVE: MSV000083544
Experimental Models: Cell Lines
Patient-Derived PDAC cell lines (N=6)	Cristina Ferrone lab, Massachusetts General Hospital Harvard Medical School	N/A
Patient-derived cancer associated fibroblasts (CAF-1 and CAF-3)	Ting lab, Massachusetts General Hospital Harvard Medical School	N/A
Patient-derived cancer associated fibroblasts (CAF-2)	Dr. Ulrich F. Wellner Clinic of Surgery, UKSH Campus Lübeck, Germany and Dr. Oliver Schilling Institute of Pathology, University Medical Center Freiburg, Germany	N/A
Experimental Models: Organisms/Strains
NSG (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ)	The Jackson laboratories	Stock No: 005557
Software and Algorithms
R software	CRAN (Open Source)	Version: 3.4.0
Prism 8	Graphpad	Version: 8
Image software analysis	Visiopharm	Version: 2018.9.4.5608