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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: J Physiol. 2019 Jul 15;597(16):4325–4340. doi: 10.1113/JP278427

Figure 4. AngII increases presynaptic and postsynaptic NMDAR activity via PKC in PVN presympathetic neurons in WKY rats.

Figure 4.

A and B, Original traces and cumulative probability plots show the effect of bath application of 50 μmol/L AP5 on the frequency and amplitude of mEPSCs of labeled PVN neurons pretreated with 2 μmol/L AngII or AngII plus 1 μmol/L chelerythrine (CLT) in brain slices from WKY rats. C and D, Summary data show the effects of AP5 on the frequency (C) and amplitude (D) of mEPSCs in labeled PVN neurons pretreated with AngII or CLT plus AngII in WKY rats (AngII, n = 11 neurons from 5 rats; CLT+AngII, n = 9 neurons from 4 rats). **P < 0.01, ***P < 0.001compared with the baseline in the AngII group. E and F, Original current traces (E) and mean data (F) show the effect of AngII or CLT plus AngII on puff NMDA (100 μmol/L)–elicited currents of labeled PVN neurons recorded from WKY rats (vehicle, n = 9 neurons from 4 rats; AngII, n = 11 neurons from 5 rats; CLT+AngII, n = 10 neurons from 4 rats). ***P < 0.001 compared with the AngII group.