Figure 9.
LTD is not induced by parallel fiber stimulation alone. EPSC amplitude (percent of baseline) after different LTP protocols mimicking parallel fiber bursts instead of a complex spike. A burst of 8 parallel fiber stimulation at 100 Hz (Pi) was used at different timing intervals (time between first stimulation parallel fiber stimulation) and various repeats (2-3 times). (A): Time courses of selected protocols showing the change in EPSC amplitude over time following an LTP induction protocol with various PF burst intervals. (B): Averaged percent change in EPSC amplitude showing all LTP protocols attempted with various parallel fiber stimulation timing intervals (e.g.: P1-P2 and P2-P3). Error bars indicate SEM.