. 2019 Aug 15;29(16):2440–2441. doi: 10.1016/j.bmcl.2019.05.058

Table 2.

1,2,4-Oxadiazol-3-yl benzoic acid derivatives in RAR α, β and γ transactivation assays.^a

Compd	X	β EC₅₀ nM^a	α EC₅₀ nM^a	γ EC₅₀ nM^a	Fold Selectivity for β over α^b	Fold Selectivity for β over γ^b	cLog P^d
ATRA	–	1.9	1.2	0.9	0.6	0.5
5		1.5	18^c	28	12	19	5.1
8		4200	18	17	0.0043	0.0041	7.2
9		1.4	4	3	2.8	2.1	7.2
10		1.9	26	11	13	5.6	5.3
11		2.5	19	5.3	7.6	2	5.3
12		3.4	30	6.3	9	2	5.8
13		11	114	83	10	7.5	4.1

^a–d

See Table 1.