Fig 4. Evaluation of a 4-compartment model using FAMoS.

(A) The global model containing all possible interactions between and within the 4 different compartments considering multiplication and transition processes. (B) Simulated data for the dynamics of the different components using a sub-model as shown on the right (true model). The different crosses indicate the mean over 10 independent measurements at each time point for each compartment (see Methods for model parameterization). (C) Evaluation of all possible models of (A) against the simulated data with the 5000 best models ranked according to their AICc-values. (D) Sketch of a single FAMoS run starting with a specified model and showing the convergence towards the final selected model over time. Individual iterations indicate the changes in the selected models after each iteration by adding (red), removal (green) or swapping (blue) of individual parameters. (E) Comparing the performance of FAMoS with and without using the swap search-method based on a total of 65.535 runs, i.e., starting FAMoS with every possible (sub-)model of the global model shown in (A).