Table 3. Incidence rate ratio (IRR) and 95% Confidence intervals (CI) for IVF treatment outcome in association with cumulative risk lifestyles.

Outcome	Risk factors includeda	Exposure category	Crude IRR (95% CI)b	p-value for comparison against referencec	p-value for entire categorical variabled	p-value for interaction with AFCe
Number of aspirated oocytes	BMI, Smoking	0 risk factors	Ref.		0.007	0.568
		1 risk factor	0.86 (0.73–1.00)	0.057
		2 risk factors	0.75 (0.61–0.94)*	0.013
Number of mature oocytes	BMI, Smoking	0 risk factors	Ref.		0.031	0.431
		1 risk factor	0.88 (0.74–1.04)	0.124
		2 risk factors	0.78 (0.62–0.98)*	0.034

^a Risk factors were identified in the “Lifestyle study” cohort

^b Validation models were run in the “UppSTART cohort”

^c Single wald p-value for the pairwise comparison of having X risk factors against the reference of 0 risk factors

^d Likelihood ratio test p-value for the categorical variable “number of risk factors”

^e Likelihood ratio test p-value for the interaction of continuous AFC with the categorical variable “number of risk factors

* p<0.05