. 2019 Aug 16;14(8):e0221015. doi: 10.1371/journal.pone.0221015

Table 4. Interaction between individual risk lifestyle factors with Antral Follicle Count (AFC) in affecting number of mature oocytes (IRRs with related 95% confidence intervals).

Outcome	Variable	Lifestyle study cohort					UppStART study cohort
Outcome	Variable	Crude IRR^a	Crude P-value^b	Adjusted IRR^c	Adjusted P-value^d	Crude interaction P-value	Crude IRR^a	Crude P-value^b	Adjusted IRR^c	Adjusted P-value^d	Crude interaction P-value
Number of mature oocytes	BMI	1.00 (0.99, 1.01)	0.948	1.00 (0.99, 1.01)	0.923	0.065	1.00 (0.99, 1.01)	0.780	1.00 (0.99, 1.01)	0.964	0.038
	Smoking	0.99 (0.94, 1.04)	0.627	0.98 (0.93, 1.04)	0.583	0.034	1.01 (0.97, 1.06)	0.559	1.02 (0.97, 1.06)	0.498	0.743
	Age	1.00 (1.00, 1.01)	0.646	1.00 (1.00, 1.01)	0.850	0.160	1.00 (0.99, 1.00)	0.824	1.00 (1.00, 1.01)	0.883	0.766
	Alcohol	1.05 (1.00, 1.11)	0.070	1.06 (1.00, 1.12)	0.058	0.303	0.95 (0.91, 1.00)^*	0.049	0.94 (0.90, 0.99)^*	0.026	0.380
	Caffeine	1.00 (1.00, 1.00)	0.960	1.00 (1.00, 1.00)	0.701	0.559	1.00 (1.00, 1.00)	0.209	1.00 (1.00, 1.00)	0.157	0.664
	Physical activity	1.07 (0.83, 1.38)	0.617	1.08 (0.83, 1.40)	0.556	0.051	0.93 (0.81, 1.08)	0.363	0.92 (0.80, 1.07)	0.271	0.908
	Depression	0.99 (0.93, 1.05)	0.791	1.00 (0.94, 1.06)	0.954	0.850	0.99 (0.93, 1.05)	0.700	0.99 (0.93, 1.05)	0.700	0.844

^a Incidence rate ratio + 95% CI for the crude univariable analysis

^b Likelihood ratio test p-value for the crude univariable analysis

^c Incidence rate ratio + 95% CI for the adjusted analysis

(adjusted for age, BMI, smoking, alcohol consumption, daily caffeine consumption, physical activity score, and history of depression)

^d Likelihood ratio test p-value for the adjusted analysis

* p<0.05