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. 2019 May 15;27(8):1424–1435. doi: 10.1016/j.ymthe.2019.05.002

Figure 4.

Figure 4

FS14-NP/siRNA Accumulation in Inflammatory Joints

Arthritic mice were injected intravenously with (a) FS14-NP/Cy5.5-siRNA, (b) free Cy5.5-siRNA, and (c) PBS. (A) In vivo imaging showing accumulation of FS14-NP/Cy5.5-siRNA in arthritic joints at 24 h after injection. (B) Organs and (C) paws were imaged after 24 h injection. (D) Co-localization of FS14-NP/Cy5.5-siRNA (red) with synovial macrophages (F4/80, green). Nuclei were stained with DAPI (blue), and blood vessels (V) are outlined (white). Scale bars, 50 μm.