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. 2019 May 15;27(8):1407–1414. doi: 10.1016/j.ymthe.2019.05.001

Figure 4.

Figure 4

Life-Long AAV-Mediated CRISPR Genome Editing Did Not Induce Detectable Toxicity or Tumor Development in mdx Mice

(A–C) Measurements of serum BUN (A), ALT (B), and AST (C) in WT, mdx, and mdx-AAV mice. *p < 0.05, **p < 0.01, ***p < 0.001. (D) Genomic DNA PCR analysis of dystrophin gene editing of various tissues (Diaph., diaphragm; GA, gastrocnemius; QU, quadriceps) from an AAV-treated mdx mouse. (E) Representative H&E-stained images of the liver from mdx and AAV-treated mdx mice. Scale bar, 50 μm. Error bars indicate mean ± SEM.