Skip to main content
. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Pharmacol Biochem Behav. 2019 Jul 18;184:172740. doi: 10.1016/j.pbb.2019.172740

Figure 4: Adolescent binge ethanol enhances the alcohol deprivation effect (ADE) in males.

Figure 4:

After completing the experiments in Figure 3, all mice underwent 2-bottle choice paradigm using ethanol (15%) vs water for additional 5 days. The last measurement of daily ethanol intake was recorded as pre-ADE. After recording last measurement, ethanol was taken from the cages, and mice underwent a-week duration of alcohol deprivation. Then, mice were re-exposed to ethanol (15%) vs water in 2-bottle choice paradigm. Mice which exposed to DID ethanol during adolescence (EE) showed an increase of ethanol intake (A) and ethanol preference (B) as compared to mice which only exposed to 2-bottle choice ethanol during adulthood (WE). Data are presented as the mean± SEM of 7 animals per group. *p<0.05. W= water; E = ethanol.