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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Pharmacol Biochem Behav. 2019 Jul 18;184:172740. doi: 10.1016/j.pbb.2019.172740

Figure 6: The impact of ethanol exposure during adolescence on ethanol LORR in adulthood.

Figure 6:

Mice exposed to 20% v/v ethanol (EE) vs. water only (WE) in the DID paradigm during adolescence and then tested at PND 72 with 3.5g/kg ethanol (20%v/v, i.p.) and monitored for the onset and duration of loss of righting reflex (LORR). Panel (A) depicts latency for the onset of LORR in sec. Panel (B) depicts LORR duration in min. Panel (C) depicts blood ethanol concentration (BEC) at the loss of function (LOF) and LORR recovery. Panel (D) depicts acute functional tolerance (AFT) score calculated as the difference between BEC at LORR recovery (BEC2) versus BEC at LORR onset (BEC1). * p<0.05 vs. WE group. Data represents the mean± SEM of 10 animals per group. W= water; E = ethanol.