Table 5.
Brain regions with GMVs smaller in ASD and associated with RRB symptoms
Region | Right/left | Peak coordinate (MNI) |
ASD vs TD | Association with RRB symptoms (RRB = 0 vs RRB ≥ 1) |
|||
---|---|---|---|---|---|---|---|
X | Y | Z | t-value | t-value | p-value | ||
Dataset collected at University of Utah | |||||||
Amygdala | Right | 30 | −2 | −20 | 4.7 | 0.64 | 0.53 |
ACC | Right | 8 | 44 | 8 | 4.6 | −0.84 | 0.41 |
Anterior insula | Right | 36 | 22 | 0 | 4.2 | 0.75 | 0.46 |
pSPL | Right | 32 | −54 | 50 | 4.6 | 2.7 | 0.014 |
Dataset collected at ETH Zürich | |||||||
Hippocampus | Right | 26 | −4 | −22 | 4.2 | 0.39 | 0.71 |
Anterior insula | Right | 36 | 14 | −10 | 3.9 | 0.83 | 0.43 |
pSPL | Right | 30 | −52 | 58 | 4.1 | 2.8 | 0.022 |
t-values and p-values in “RRB = 0 vs RRB ≥ 1” indicate results of two-sample t test of GMVs between the ASD individuals with zero RRB scores and those with ≥1 RRB scores. Positive t-values denote that the GMVs were larger in individuals with zero RRB, whereas the negative values indicate that the GMVs were smaller.