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. 2019 Aug 16;8:e46321. doi: 10.7554/eLife.46321

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© 2019, LeMessurier et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Author response image 1. — Data are from a new cohort of 6 NH and 6 EN mice, all C57BL/6 wild-types. Surgery for headplate and cranial window implant was on Day 0. A. Daily weight during surgical recovery. Mean recovery to pre-surgical weight was 4 days (NH) or 5.5 days (EN). B. Spontaneous behaviors quantified in a clean open-field environment. Time spent in each behavior was calculated with 30-sec resolution. ‘Still’ indicates 30-sec periods in which neither locomotion, grooming or rearing occurred. Behavior was recorded daily and analyzed in 2-day windows. Circles and bars are bootstrapped medians and 95% confidence intervals. P-values are for permutation test for difference between NH and EN in total area under the curve. There were no significant differences between NH and EN in any behavior (α = 0.05).