Table 1.
Baseline Characteristics of the Study Population
| Men with HIV (n=279) | Men without HIV (n=379) | P-value | |
|---|---|---|---|
| Age | 61.1 (55.6,64.2) | 62.4 (58.5,66.8) | <0.001 |
| Race | |||
| White | 199(71%) | 312(82%) | 0.001 |
| Black | 67(24%) | 47(12%) | |
| Other | 13(5%) | 20(5%) | |
| Study Site | |||
| Baltimore | 64(23%) | 93(25%) | 0.005 |
| Chicago | 87(31%) | 73(19%) | |
| Pittsburgh | 64(23%) | 109(29%) | |
| Los Angeles | 64(23%) | 104(27%) | |
| Late cohort (enrolled after 2001) | 72(26%) | 50(13%) | <0.001 |
| Smoking status | |||
| Non-smoker | 78 (32%) | 131 (35%) | 0.57 |
| Former smoker | 143 (52%) | 195 (52%) | |
| Current smoker | 45 (16%) | 51 (14%) | |
| Physical activity | 0.77 | ||
| Low | 58(21%) | 80(21%) | |
| Moderate | 75(27%) | 109(29%) | |
| High | 145(52%) | 185(49%) | |
| Body mass index | 25.2(22.8,28.4) | 26.1(23.5,29.9) | 0.004 |
| Diabetes | 45(18%) | 42(12%) | 0.034 |
| Controlled (HbA1C <7.5%) | 37 (13%) | 32 (9%) | |
| Uncontrolled (HbA1C ≥ 7.5% | 7 (3%) | 12 (3%) | |
| Diabetes medications | 37(13%) | 37(10%) | 0.16 |
| Non-insulin therapy | 28 (10%) | 28 (7%) | |
| Insulin | 10 (4%) | 10 (3%) | |
| Depression medications | 81(30%) | 67(18%) | <0.001 |
| Illicit drug use | 130(48%) | 157(42%) | 0.14 |
| Peripheral neuropathy | 135(51%) | 143(40%) | 0.48 |
| Neuroimpairment | 15(7%) | 15(5%) | 0.51 |
| HIV-1 RNA <50 copies/mL | 255(91%) | - | |
| CD4 ≥ 500 cells/uL | 201(73%) | - | |
| Nadir CD4 <200 cells/uL | 101(36%) | - | |
| Current use of efavirenz | 30(11%) | - | |
| ABC ≤ 80 | 25 (9%) | 28 (7%) | 0.48 |
| ABC ≤ 90 | 66 (24%) | 81 (21%) | 0.51 |
| ABC-6 ≤ 80 | 55 (20%) | 71 (19%) | 0.78 |
| ABC-6 ≤ 90 | 116 (42%) | 153 (41%) | 0.80 |
| Tandem Stand (unable) | 126 (45%) | 149 (29%) | 0.13 |
| Functional Reach | 30.7 (25.5, 36.2) | 31.8 (26.1, 37.0) | 0.32 |
| 10-time chair rise | 23.9 (19.1, 26.8) | 23.1 (19.2, 27.6) | 0.84 |
| Grip Strength | 37 (30, 41) | 35 (30, 41) | 0.24 |
| Gait speed | 3.7 (3.4, 4.2) | 3.8 (3.3, 4.1) | 0.15 |
| SPPB Score <10 | 41 (15%) | 51 (13%) | 0.65 |
| Frailty Score | 0.09 | ||
| Non-frail | 158 (57%) | 235 (62%) | |
| Pre-frailty | 102 (37%) | 131 (35%) | |
| Frailty | 19 (7%) | 13 (3%) |
ABC, activities-specific balance confidence; SPPB, short physical performance battery