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. Author manuscript; available in PMC: 2020 Mar 14.
Published in final edited form as: J Phys Chem B. 2019 Mar 5;123(10):2217–2234. doi: 10.1021/acs.jpcb.8b10946

Figure 1:

Figure 1:

Two-state gene expression example. (A) CPU time vs number of iterations for a sample run of the ADAMH-FSP-Krylov and the AMH-FSP. (B) Scatterplot of the unnomarlized log-posterior evaluated using the full FSP and the reduced model. Notice that the approximate and true values are almost identical with a correlation coefficient of approximately 0.99853. (C) Distribution of the relative error in the approximate log-likelihood evaluations at the parameters accepted by the ADAMH chain. (D) 2-D projections of parameter combinations accepted by the ADAMH scheme (blue) and parameter combinations used for reduced model construction (red).