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. Author manuscript; available in PMC: 2020 Mar 14.
Published in final edited form as: J Phys Chem B. 2019 Mar 5;123(10):2217–2234. doi: 10.1021/acs.jpcb.8b10946

Figure 6:

Figure 6:

Genetic toggle switch example. Autocorrelation in the outputs of the Adaptive Delayed Acceptance Metropolis-Hastings with Krylov reduced model (ADAMH-FSP-Krylov), the Adaptive Metropolis-Hastings with full FSP (AMH-FSP), and the Hybrid method for the parameters k0X, k1X, γX, k0Y, k1Y, γY. The autocorrelation is estimated directly in log10-transformed space of parameters, where the chains draw their proposals.