Genetic toggle switch example. Autocorrelation in the outputs of the Adaptive Delayed Acceptance Metropolis-Hastings with Krylov reduced model (ADAMH-FSP-Krylov), the Adaptive Metropolis-Hastings with full FSP (AMH-FSP), and the Hybrid method for the parameters k0X, k1X, γX, k0Y, k1Y, γY. The autocorrelation is estimated directly in log10-transformed space of parameters, where the chains draw their proposals.