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. Author manuscript; available in PMC: 2019 Aug 16.
Published in final edited form as: Nature. 2018 Jun 6;558(7708):73–79. doi: 10.1038/s41586-018-0175-2

Extended Data Fig. 4. The WFIKKN2 region is a trans pQTL for GDF11/8 plasma levels.

Extended Data Fig. 4

a, Regional association plots of the trans pQTL (sentinel variant rs11079936) for GDF11/8 before and after adjusting for levels of WFIKKN2 (upper panels), and the WFIKKN2 cis pQTL after adjusting for GDF11/8 levels (bottom panel). A similar pattern of association for WFIKKN2 was seen before GDF11/8 adjustment (not shown). b, Attenuation of the GDF11/8 trans pQTL upon adjustment for plasma levels of the cis protein WFIKKN2.