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Confocal imaging of MDA-MB-468 incubated for 24h with 1 mg/mL of unconjugated NPs as well as particles reacted with AlexaFluor 488 modified cytosine deaminase conjugated with either polyadenine or polythymine DNA. As shown, green fluorescence from the AlexaFluor488 dye was only detected from cells incubated with PEG-CNA(T10)-PLGA nanoparticles reacted with poly-A conjugated CodA, demonstrating the specificity of CNA-DNA hybridization. Scale bars represent 50 μm.
