Figure 4:

Effects of oxytocin on yohimbine-induced reinstatement in female mice. Active and inactive lever responses (a), number of alcohol reinforcers earned (b), and alcohol intake (c) over the last 3 days of oral alcohol self-administration. Similar to males, yohimbine treatment increased alcohol responding during reinstatement testing and this effect was attenuated by pretreatment with OXT (1 mg/kg) (d). Values are mean ± s.e.m. (N= 7–10/group). Significantly differs from average last 3 days of extinction (ext): ** (p< 0.01). Significantly differs from vehicle condition: ^ (p< 0.05).