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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Curr Opin Struct Biol. 2019 Mar 16;57:84–92. doi: 10.1016/j.sbi.2019.01.017

Figure 1. Fully genetically encoded strategies for optically inducible intracellular signaling by integral membrane and membrane-associated proteins in mammalian cells.

Figure 1.

Examples schematized are underlined. Abbreviations: POI = protein of interest. BD = binding domain, CIBN = cryptochrome interacting binding partner, CRY2 = cryptochrome, ER = endoplasmic reticulum, Gq* = activated Gαq, IP3 = inositol triphosphate, IP3R = IP3 receptor, LOV = light-oxygen-voltage, PLC = phospholipase C, Rec = membrane receptor.