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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Ann N Y Acad Sci. 2019 Jun 23;1450(1):190–203. doi: 10.1111/nyas.14167

Table 2.

Proposed adjustmentsa to hemoglobin (g/L) by 500-m increments of altitude by population group

Altitude (m) WHO
cutoffsb
MMWR 1989
equationc
PSCd WRAe
−50 to −1 0 0 0 0
0 0 0 0 0
1–499 0 0 1 1
500–999 0 1 4 4
1000–1499 2 2 7 7
1500–1999 5 5 10 10
2000–2499 8 10 13 13
2500–2999 13 15 16 17
3000–3499 19 22 20 20
3500–3999 27 29 24 24
4000–4499 35 38 28 28
a

Adjustment is amount (g/L) added to the hemoglobin cutoff defining anemia, or subtracted from an individual’s observed hemoglobin level.

b

WHO cutoffs published as the lowest altitude value in range (e.g., 1500 m for the 1500−1999 range).2

c

MMWR cutoffs calculated using Hb_adjustment (g/L) = [(−0.032 × (altitude × 0.0032808) + 0.022 × (altitude × 0.0032808)2) × 10], where altitude is based on the midpoint of altitude range (e.g., 1750 m for the 1500−1999 range).8,10

d

Proposed cutoffs calculated using Hb_adjust_altitude (g/L) = (0.0048108 × altitude) + (0.0000004 × altitude2), where altitude is based on the midpoint of altitude range (e.g., 250 m for the 1−499 range).

e

Proposed cutoffs calculated using Hb_adjust_altitude (g/L) = (0.0052792 × altitude) + (0.0000003 × altitude2), where altitude is based on the midpoint of altitude range (e.g., 250 m for the 1−499 range).

Note: Current WHO recommendations and adjustments based on the MMWR 1989 equation provided for comparison.

PSC, preschool-aged children (6−59 months); WRA, women of reproductive age (15−49 years).